NEWS
| 2022-04-27 | PNA Oligo ( 肽核酸 ) 協助你的分子生物實驗更加穩定 |
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PNA(Peptide nucleic acid )為具有類多肽骨架的DNA類似物，可以經由人工合成製造，PNA 具有一種結構N-(2-aminoethyl) glycine。使對於標的的DNA或RNA結合親和力和穩定性大大提高。儘管骨架的結構變化，但 PNA 可用於 DNA 的各種應用，因為它可以像 DNA 一樣與標的序列互補結合。特點：
| PNA | DNA | |
| Binding Affinity | At Least 1°C Higher Tm per Base | - |
| Hybridization rate | 100-5000 Times Faster | - |
| Salt concentration in hybridization | Independent | Dependent |
| ΔTm for single nucleotide mismatch | <10°C | <15°C |
| ChemicalStability | Stable | Unstable in Acidic or Basic condition |
| BiologicalStability | Enzyme-Resistant | Degradable by Nuclease |
相關產品：
一、Panagene Custom PNA
客製化PNA序列，可以依照不同的需要合成下列兩種方案：
1. fluorescent dye-labeled PNA可label螢光
2. unlabeled PNA
序列設計，除了一般的DNA序列之外，亦可以加入Linker ( C3-NH2, C4-NH2, C6-NH2, C12-NH2, Polyethylene Glycol linker, E linker )，Base modification (D (2,6-diaminopurine), J (Pseudoisocytosine), I (Inosine) )等相關的modification。
點擊連結
二、Panagene PNA FISH probe
特殊的結構可以達到更快更有效率的Hybridization，能夠選擇的probe如下表
| PNA FISH probe | Cat. No. | Product Name | Size |
| C-rich probe (repeats of CCCTAA) | F1001 | TelC-FAM | 5 nmole |
| F1002 | TelC-Cy3 | 5 nmole | |
| F1003 | TelC-Cy5 | 5 nmole | |
| F1004 | TelC-Alexa488 | 5 nmole | |
| F1009 | TelC-FITC | 5 nmole | |
| F2003 | TelC-Alexa647 | 5 nmole | |
| F2005 | TelC-Biotin | 5 nmole | |
| F2001 | TelC-TAMRA | 5 nmole | |
| G-rich probe (repeats of TTAGGG) | F1005 | TelG-FAM | 5 nmole |
| F1006 | TelG-Cy3 | 5 nmole | |
| F1007 | TelG-Cy5 | 5 nmole | |
| F1008 | TelG-Alexa488 | 5 nmole | |
| F1010 | TelG-FITC | 5 nmole | |
| F2002 | TelG-TAMRA | 5 nmole | |
| F2004 | TelG-Alexa647 | 5 nmole | |
| F2006 | TelG-Biotin | 5 nmole | |
| Pan-centromere probe | F3003 | Cent-Cy3 | 5 nmole |
| F3006 | Cent-FAM | 5 nmole | |
| F3011 | Cent-Cy5 | 5 nmole | |
| F3012 | Cent-Alexa488 | 5 nmole | |
| F3013 | Cent-FITC | 5 nmole | |
| F3014 | Cent-TAMRA | 5 nmole | |
| F3015 | Cent-Alexa647 | 5 nmole | |
| F3016 | Cent-Biotin | 5 nmole | |
| CENPB probe | F3001 | CENPB-FAM | 5 nmole |
| F3002 | CENPB-Cy3 | 5 nmole | |
| F3004 | CENPB-Cy5 | 5 nmole | |
| F3005 | CENPB-Alexa488 | 5 nmole | |
| F3007 | CENPB-FITC | 5 nmole | |
| F3008 | CENPB-TAMRA | 5 nmole | |
| F3009 | CENPB-Alexa647 | 5 nmole | |
| F3010 | CENPB-Biotin | 5 nmole |
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